rmdopen.bmj

Benefit–risk analysis of upadacitinib versus adalimumab in patients with rheumatoid arthritis and higher or lower risk of cardiovascular disease

Objectives Evaluate the risks and benefits of upadacitinib 15 mg vs adalimumab in rheumatoid arthritis (RA) patients with an inadequate response to methotrexate based on cardiovascular (CV) risk.
RMD Open

Birth length and perinatal exposures and rheumatoid arthritis risk in the E3N cohort

Objective To examine associations between participants’ perinatal factors, including harmonised birth weight and length, ...
rmdopen.bmj

Machine learning-based multiclass model for autoimmune disease diagnosis and classification through nailfold videocapillaroscopy features

Objective To develop and validate a predictive model for distinguishing controls (Ctr), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) based on nailfold videocapillaroscopy (NVC) ...
rmdopen.bmj

Effectiveness of exercise therapy for osteoarthritis: an overview of systematic reviews and randomised controlled trials

Data sources Medline, Embase, Epistemonikos, PEDro, Cochrane and registries from inception to 8 November 2025. Eligibility criteria Reviews comparing exercise with placebo, no intervention or other ...
rmdopen.bmj

Rheumatic and musculoskeletal disorders in musicians: risks, adaptations and management

Music therapy is recognised as a complementary or alternative therapy for osteoarthritis and fibromyalgia, but playing music can have health repercussions for musicians in the field of rheumatology.
rmdopen.bmj

Efficacy of risankizumab across GRAPPA domains in psoriatic arthritis: a pooled analysis of patients from the phase 3 KEEPsAKE 1 and 2 studies

Objective To assess the efficacy of long-term treatment with risankizumab across the updated Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) domains and key related ...
rmdopen.bmj

Time sequence of autoimmune processes in the trajectory to rheumatoid arthritis development: what do we know?

The trajectory to RA development is a multi-step process that can take a decade. Understanding which processes occur at which moment during this trajectory is crucial when designing interventions to ...
rmdopen.bmj

DEUS Enthesitis Index (DEI): a new tool integrating ultrasound and clinical examination for enthesitis assessment in spondyloarthritis

Objectives (1) To develop a composite score, the DEUS (Defining Enthesitis on Ultrasound in Spondyloarthritis) Enthesitis Index (DEI), which integrates ultrasound and clinical examination findings for ...
rmdopen.bmj

Lung ultrasound outperforms symptom-based screening to detect interstitial lung disease associated with rheumatoid arthritis

Objectives Interstitial lung disease associated with rheumatoid arthritis (RA-ILD) is linked to high mortality. Currently, effective screening tools are lacking. We assessed the role of symptoms and ...
rmdopen.bmj

Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study

Objectives DARWIN 3 (ClinicalTrials.gov: NCT02065700) assessed the safety and efficacy of filgotinib in a long-term extension (LTE) of two phase II randomised controlled rheumatoid arthritis (RA) ...
rmdopen.bmj

Lymph nodes as gatekeepers of autoimmune diseases

Secondary lymphoid organs such as lymph nodes (LNs) are the home of peripheral tolerance mechanisms which control autoreactive T cells and prevent immune responses to self-antigen. In systemic ...
rmdopen.bmj

Methotrexate inhibits glucocorticoids-induced osteoclastogenesis via activating IFN-γR/STAT1 pathway in the treatment of rheumatoid arthritis

Objectives Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by the synovitis and bone erosion. The combination therapy of glucocorticoids (GCs) and methotrexate (MTX) is ...