Introduction: EBV-associated nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer that is prevalence in southern China and Southeast Asia. While radiotherapy or concurrent ...

Cyclin E (CCNE1) is amplified in multiple cancers including approximately 10% of esophagogastric cancers and 20% of ovarian cancers. CCNE1 amplification leads to DNA replication stress and chromosomal ...

Cancer Res (2025) 85 (8_Supplement_1): 1160.

Cancer Res (2026) 86 (5_Supplement_2): A010.

Abstract. A key barrier to effective immunotherapy for cancer is the immunosuppressive tumor microenvironment (TME) characterized by infiltrating regulatory T cells (Tregs) and myeloid-derived ...

Background: KRAS is a key mediator of the RAS/MAPK signaling cascade and promotes cellular growth and proliferation. It is the most frequently mutated oncogene in cancer, and KRAS G12C mutations occur ...

Major Finding: T cells expressing cellobiose-catabolizing proteins can utilize this glucose disaccharide to restore effector functions impaired by glucose withdrawal. Concept: Mammalian cells ...

1Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, ...

Defining the Antitumor Mechanism of Action of a Clinical-stage Compound as a Selective Degrader of the Nuclear Pore Complex Open Access Linjie Yuan; Wenzhi Ji; Brendan G. Dwyer; Joey Lu; Jing Bian; ...

Cancer Res (2019) 79 (13_Supplement): 5017. We previously reported that intratumoral (IT) mouse (m) IL-12 mRNA, the surrogate for MEDI1191, promotes cytotoxic T cell-dependent anti-tumor immunity and ...

Cancer Res (2022) 82 (12_Supplement): 5457. Background: The 3 rd-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI), like osimertinib, provide marked clinical benefit ...